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Active Not Recruiting
NCT06569212
Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)
Conditions: Non-Traumatic Subarachnoid Hemorrhage
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE4
Enrollment: 20
Sponsor: Madeleine Puissant
Location: MaineHealth Portland Maine
Summary
To determine the effect of early metoprolol administration after non-traumatic subarachnoid hemorrhage (SAH).
Eligibility Criteria
Inclusion Criteria:
* \>18 years of age
* Neuro-imaging confirmed non-traumatic subarachnoid hemorrhage
Exclusion Criteria:
* Traumatic cause of subarachnoid hemorrhage (e.g. fall, motor vehicle accident, other blunt trauma) as this is a different mechanism of hemorrhage.
* Other forms of traumatic or non-traumatic intracranial bleed including intracerebral hemorrhage (ICH), subdural hemorrhage, epidural hemorrhage
* Pregnancy (as the study medication, metoprolol, has FDA Pregnancy Category C rating)
* Unstable vital signs not amenable to beta-1 adrenergic receptor inhibitor (B1ARi) administration including:
* Systolic blood pressure \< 80 mmHg not stabilized on vasopressor medications
* Heart rate \< 50 bpm associated with hypotension
* Patients requiring vasopressor agents due to hypotension (SBP \
Source: ClinicalTrials.gov (NCT06569212). StuddyBuddy aggregates publicly available trial information.