Mindfulness-Based Substance Use Prevention (MINDS-UP)

The goal of this clinical trial is to test the feasibility, behavioral/neural mechanisms, and preliminary efficacy of "MINDfulness-based Substance Use Prevention Program," or "MINDS-UP", a novel substance use prevention meditation intervention for children and adolescents between the ages of 10 and 14. The aims of the study are: Aim 1: Determine feasibility and acceptability of MINDS-UP as a preventive intervention via a) retention, b) attendance, c) teacher-rated participation, d) student-rated participation, e) homework completion, and f) acceptability. Aim 2: Evaluate neuropsychological mechanisms (target engagement) of MINDS-UP. Aim 3 (Exploratory): Assess preliminary efficacy of MINDS-UP on substance use initiation (SUI).

Inclusion Criteria: 1. Youth is ages 10-14 years on the day of screening \[i.e., does not turn 15 before or on the day of screening\] 2. Youth has access to a smartphone, tablet, or computer with Wi-Fi 3. Youth and parent are English-speaking Exclusion Criteria: 1\. The youth has been diagnosed with or received treatment for one of the following mental health problems: depression, bipolar disorder, schizophrenia, autism spectrum disorder, intellectual disability, or substance use disorder.