Telerehabilitation In The Home After Stroke

The purpose of this research study is to evaluate whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone. Patients with arm weakness due to stroke that happened in the past 90-150 days will be randomized into one of two groups: \[1\] TR and usual care; \[2\] usual care only (no TR), but people in the usual care group will be offered TR once the study is done. TR consists of 70 minutes/day of activities targeting arm function, 6 days a week for 6 weeks.

Inclusion Criteria: 1. Age 18-80 years at the time of randomization 2. The index stroke was radiologically verified, due to ischemia or intracerebral hemorrhage (ICH), and had time of onset 120±30 days prior to randomization 3. The stroke caused upper extremity deficits as defined by Action Research Arm Test score 18-44 (out of 57) at Baseline Visit 1 4. Box \& Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit 1 5. Able to successfully perform all 3 rehabilitation exercise test examples (simple commands) at Baseline Visit 1 6. Informed consent and behavioral contract signed by the subject (i.e., no surrogate consent) Exclusion Criteria: 1. A major, active, coexistent neurological, psychiatric, or medical disease that reduces the likelihood that a subject will be able to comply with all study procedures 2. Unable or unwilling to perform study procedures/therapy, or expectation of noncompliance with study procedures/therapy, or expectation that subject cannot participate in all study visits 3. A diagnosis (apart from the index stroke) that substantially affects paretic arm function 4. Severe depression, defined as Geriatric Depression Scale Score \>10/15 at Baseline Visit 1 5. Significant cognitive impairment, defined as Montreal Cognitive Assessment score \2 prior to the index stroke 9. A new symptomatic stroke has occurred since the index stroke, or a separate stroke occurred within 30 days prior to the index stroke 10. Lacking visual acuity, with or without corrective lens, of 20/50 or better in at least one eye 11. Life expectancy \< 9 months 12. Pregnant; women of child-bearing potential must have a negative pregnancy test 13. Botulinum toxin to the paretic arm: received in the prior 3 months OR expected by the 8-Month Visit 14. Concurrent enrollment in another therapy-based investigational study where the duration of the investigational therapy's activity is likely to occur during the subject's participation in the study 15. Subject lacks sufficient English or Spanish to comply with study procedures and TR instructions 16. Expectation that subject will not have a single domicile address during the 6 weeks of therapy that is within 1.5-hr drive of the central study site \[this can be waived at the discretion of the site PI\] 17. Contraindication to MRI 18. On isolation precautions, e.g., due to active COVID-19