Recording Cutaneous Vagal Nerve Activity With Multi-Electrode Array (MEA) in Patients Undergoing VNS Therapy

The overall purpose of the ABVN Phase 2 grant is to expand on previous work evaluating vagal nerve function. This will be accomplished through several independent, but related, studies. The purpose of this study is to find out if it is possible to record compound nerve action potentials through the skin surface from participants who have previously had a vagus nerve stimulation device implanted as part of clinical care.

Inclusion Criteria: * Volunteers with no GI symptoms * Ages 18-80 * Undergoing VNS Therapy as part of clinical treatment for focal or partial epilepsy or seizure * Willing to have MEA electrodes placed on the neck and bipolar electrodes placed on chest and stomach Exclusion Criteria: * Unable to provide consent or has no LAR * Having gastric motility issues (not due to COVID 19) as determined by the PI or Sub I * Taking medications affecting gastric motility * Pregnant females * Prisoners