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Completed
NCT06904365
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Conditions: Uterine Cancer, Rectal Cancer, Colon Cancer, Breast Cancer, Lung Cancer, Sarcoma, Cervix Cancer, Head and Neck Cancer, Anal Cancer, Liver Cancer, Gastric Cancer, Bladder Cancer
Sex: Female
Ages: 18 Years – 50 Years
Healthy volunteers: No
Enrollment: 10
Sponsor: Washington University School of Medicine
Location: Washington University School of Medicine St Louis Missouri
Summary
Female patients with early onset (\
Eligibility Criteria
Inclusion Criteria:
* Biologic female
* Age between 18 and 50 years old (inclusive)
* Clinically premenopausal (defined as having active, regular menstruation without vasomotor symptoms)
* At least one of two ovaries readily visualized on diagnostic CT or MR imaging as confirmed by radiologist
* Planning to receive radiation therapy (for any indication)
* Ability to understand and willingness to sign an IRB-approved written informed consent document.
Exclusion Criteria:
* Prior pelvic radiation
* Prior cancer therapies that are known to impact ovarian function
* Prior diagnosis of ovarian insufficiency/failure or menopause
* Clinically peri- or post-menopausal
* For patients \> 45 years old, if there is a clinical history of vasomotor symptoms OR irregular periods, then the patient must be excluded.
* For patients ≤ 45 years old, if there is a history of vasomotor symptoms consistent with menopause OR irregular menstruation for ≥3 months OR recent changes in their menstrual cycle \> 14 days, then the patient must be excluded.
* Surgically removed or transposed ovaries
* Pregnant and/or breastfeeding
Source: ClinicalTrials.gov (NCT06904365). StuddyBuddy aggregates publicly available trial information.
