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NCT06910293
Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation
Conditions: Neural Activity, Brain Function, Neurodynamics, Brain Connectivity
Sex: Female
Ages: 25 Years – 35 Years
Healthy volunteers: Yes
Enrollment: 15
Sponsor: ART Fertility Clinics LLC
Location: ART Fertility Clinics LLC Abu Dhabi Abu Dhabi Emirate
Summary
The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.
Eligibility Criteria
Inclusion Criteria:
* Age group: 25 - 35 years old
* BMI: 20 - 30
* Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml
* Regular Menstrual Cycle: 26-35 days
* In case of previous use of hormonal contraception: wash-out period of 3 month
* Meet standard safety and eligibility criteria for MRI scanning, including the absence of contraindications such as metallic implants, claustrophobia, or other medical conditions that preclude MRI
Exclusion Criteria:
* History of ovarian surgery
* Pathology of the ovaries
* Mental health disorders
* Use of medication influencing brain function
* Ongoing use of hormonal contraception (this would include OCP, but also patches and Mirena containing IUD)
Source: ClinicalTrials.gov (NCT06910293). StuddyBuddy aggregates publicly available trial information.