Hand Jing-Well Points Stimulation to Treat Disorders of Consciousness

The purpose of this academic lead study is to explore the ideal stimulation strategies at Hand twelve jing-well points in patients with disorders of consciousness.

Inclusion Criteria: * Age: 18-80 years old * From 7 to 90 days since brain injury * Diagnosed in VS/UWS or MCS as defined by at least two CRS-R assessments performed during the screening period * Acquired cerebral damage of known etiology * Intact hand skin * Informed consent given by the legal surrogate Exclusion Criteria: * Patients who continuously receive sedative drugs and Na+ or Ca2+ channel blockers (e.g., carbamazepine) or NMDA receptor antagonists (e.g., dextromethorphan) * History of previous serious、progressive neurological disorder prior to the brian injury * Epilepsy and seizure * Unstable vital signs or life-threatening comorbidities * Active implant (e.g., cardiac pacemakers/defibrillators, deep brain stimulators, ventriculoperitoneal shunt, etc) * Documented pregnancy