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NCT06953388
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD
Conditions: PTSD - Post Traumatic Stress Disorder
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: No
Phase: EARLY_PHASE1
Enrollment: 60
Sponsor: Wayne State University
Location: Tolan Park Research Clinic, Wayne State University Detroit Michigan
Summary
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma. To answer these questions, we measure bodily responses (heart rate, sweat, startle) and questionnaires. The main questions it aims to answer are:
Does non-invasive vagus nerve stimulation help reduce anxious arousal? Does non-invasive vagus nerve stimulation help dampen learned fear?
Eligibility Criteria
Inclusion Criteria:
1. Ages 18-80
2. Fluent in English
3. Experience with a DSM-5 Criterion A trauma (LEC-5)
4. Probable PTSD (PCL-5 ≥ 32)
Exclusion Criteria:
1. Visual or Auditory impairment
2. Major injury at time of screen or study procedures
3. Taking ≥20 mg morphine per day
4. Current substance use or intoxication (12-panel drug test)
5. Intellectual disability (MoCA)
6. Self-inflicted injury
7. Occupational injury
8. Prisoner
9. Ongoing domestic violence
10. Pregnant or breastfeeding
11. Contraindications for taVNS
Source: ClinicalTrials.gov (NCT06953388). StuddyBuddy aggregates publicly available trial information.
