Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis

The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).

Inclusion criteria for individuals with T2D and elevated liver fat ≥5.6% 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or (pre-menopausal) female, aged 25-55 years 4. Body mass index (BMI) between 25 and 45 kg/m2 5. Sedentary (1 day or less per week of structured exercise) 6. Type 2 diabetes mellitus: HbA1c ≥7.5% 7. Liver fat ≥5.6% based on MRI 8. Weight stable (± 2 kg) for prior 3 months Inclusion criteria for lean, healthy controls 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or (pre-menopausal) female, aged 25-55 years 4. Body mass index (BMI) between 18.5 and 27.5 kg/m2 5. Normal liver fat (FibroScan CAP \