Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.

Participants must be residents of Illinois or Missouri and able to come to St. Louis offices in person. Inclusion Criteria: * Ages 50-70 * Able to come to the research center for testing and intervention visits. * Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)). * BMI≥27 or Body Roundness index ≥6 * Able to provide informed consent. Exclusion Criteria: * Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records. * Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation. * Unable to perform study assessments. * Alcohol or substance abuse within 6 months per self-report or medical records. * Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity. * Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine) * PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention