Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.

Inclusion Criteria: * Admitted to intensive care unit (ICU) * Age 18 years or older * Requiring invasive mechanical ventilation for at least 24 hours * Pass spontaneous breathing trial screen criteria Exclusion Criteria: * Do not intubate (DNI) order * Presence of tracheostomy * Pregnancy * Known prisoner * Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures * Enrolled in another clinical trial that impacts ventilator weaning or liberation * Receive veno-venous extracorporeal membrane oxygenation (VV-ECMO)