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NCT07019636
Direct Extubation Versus Extubation After a Spontaneous Breathing Trial in Patients at Low Risk of Extubation Failure
Conditions: Weaning From Mechanical Ventilation, Extubation
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: No
Phase: NA
Enrollment: 314
Sponsor: Assistance Publique - Hôpitaux de Paris
Location: Hôpital Pitié Salpêtrière Paris
Summary
This randomized controlled open label trial aims at comparing a weaning strategy including a spontaneous breathing trial as a prerequisite for extubation to a weaning strategy without a spontaneous breathing trial (direct extubation) in patients with readiness to be weaned criteria and considered at low risk of extubation failure. The main endpoint will be the proportion of patients successfully extubated within the 24 hours after randomization as compared to extubation after a successful spontaneous breathing trial (SBT).
Eligibility Criteria
Inclusion Criteria:
* Age older than 18 years and \< 65 years old
* Nasal or oral intubation longer than 24 hours and less than 4 days
* Satisfaction to each following weaning readiness criteria:
1. Respiratory rate \< 35 cycles per minute
2. SpO2 \>90% with FiO2\
Source: ClinicalTrials.gov (NCT07019636). StuddyBuddy aggregates publicly available trial information.
