Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Phase: NA

Enrollment: 10

Sponsor: Beth Israel Deaconess Medical Center

Summary

The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by Electrical Impedance Tomography (EIT) and esophageal pressure measurements on lung mechanics and V/Q optimization.

Eligibility Criteria

Inclusion Criteria: * Adults (≥18 years) undergoing mechanical ventilation during peripheral VA ECMO support for cardiogenic shock, cardiac arrest, or refractory heart failure. * On ECMO support for at least 6 hours * Swan-Ganz catheter required as standard clinical care * Clinically stable in the estimation of the study investigator Exclusion Criteria: * Contraindications to EIT (e.g., presence of electrical interference) * Patients without pulmonary flow (non-pulsatile pulmonary pressure) * Patients with known pulmonary embolism * Imminent withdrawal of life support

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07141524). StuddyBuddy aggregates publicly available trial information.