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Recruiting
NCT07162337
BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
Conditions: Colorectal Cancer Prevention, Colorectal Adenoma
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: No
Phase: NA
Enrollment: 40
Sponsor: Massachusetts General Hospital
Location: Massachusetts General Hospital Cancer Center Boston Massachusetts
Summary
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating biomarkers and gene expression associated with colonic bile acid receptor activation and colorectal cancer.
Eligibility Criteria
Inclusion Criteria:
* Underwent screening or surveillance colonoscopy with removal of at least one adenoma.
* Age 18-80 years.
* Habitually consume a Western pattern diet.
* BMI of at least 18.5 kg/m2 but less than 35 kg/m2
* Weight stable in last 3 months (loss or gain \
Source: ClinicalTrials.gov (NCT07162337). StuddyBuddy aggregates publicly available trial information.
