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Recruiting
NCT07174349
Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
Conditions: Urinary Retention Postoperative
Sex: All
Ages: 35 Years – N/A
Healthy volunteers: No
Phase: PHASE4
Enrollment: 20
Sponsor: Mayo Clinic
Location: Mayo Clinic in Rochester Rochester Minnesota
Summary
The purpose of this research is to see if the use of tamsulosin can decrease both the incidence and duration of urinary retention, as well as hospital length of stay following spine surgery.
Eligibility Criteria
Inclusion Criteria:
* Cervical Laminectomy
* Cervical Posterior Fusion
* Cervical Anterior/Posterior Fusion
* Lumbar Laminectomy
* Lumbar Posterolateral Fusion
* Lumbar Interbody Fusion
Exclusion Criteria:
* Cervical Anterior Discectomy and Fusion
* Cervical Anterior Corpectomy
* Cervical Posterior Discectomy
* Cervical Foraminotomy
* Lumbar Discectomy (METRx or Open)
* Lumbar Foraminotomy
* Lumbar Anterior Fusion
* Myelopathy with bladder dysfunction
* Patients currently taking an alpha-antagonist
o The following drugs are alpha antagonists: alfuzosin, doxazosin, prazosin, terazosin, tamsulosin, and phenoxybenzamine.
* Patients with history of allergy or sensitivity to tamsulosin or other alpha-antagonist
* History of prostatectomy or urologic surgery involving the bladder or urethra
* Severe liver disease or end-stage renal disease
* Patients taking strong inhibitors of CYP3A4
o The following drugs are strong inhibitors of CYP3A4: ketoconazole, itraconazole, clarithromycin, ritonavir, indinavir/ritonavir, lopinavir/ritonavir, and conivaptan.
* Mental disability or prisoner
* Pregnancy (for anesthesia purposes)
Source: ClinicalTrials.gov (NCT07174349). StuddyBuddy aggregates publicly available trial information.