Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes

Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes The goal of this clinical trial is to evaluate of the involvement of Neutrophil extracellular traps in the evolution of hepatocellular cancer. The main questions it aims to answer are: * How does the type of anesthesia used in hepatobiliary oncological surgery influence postoperative evolution and the immune response? * How does the type of anesthesia, TIVA versus inhalational influence the generation of neutrophil extracellular traps (NETs)? Researchers will compare the evolution of the patients assigned to 4 study groups depending on the anesthetic intervention performed. Participants will: * will be evaluated pre and postanesthesia, blood samples will be collected for analysis of the inflammatory response * will be followed up one year for establishing the outcome

Inclusion Criteria: * Diagnosed with: hepatocellular carcinoma, or hepatic metastases * Scheduled for elective liver surgery: Exclusion Criteria: * Undergoing emergency surgery * Barcelona-Clinic Liver Cancer stage C; * Child-Pugh Class C * Receiving chronic immunosuppressive therapy * Having contraindications to any of the study medications * Diagnosed with psychiatric disorders, such as: depression, bipolar disorder, schizophrenia, having autoimmune diseases * Suffering from corticosteroid-dependent bronchial asthma * Diagnosed with congenital or acquired coagulation disorders