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NCT07220031
Effect of Activated Charcoal on Serum Osmolality, Osmolal Gap, and Enzymatic Ethylene Glycol Assay
Conditions: Osmolality Disturbance, Lab Interference
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Enrollment: 8
Sponsor: State University of New York - Upstate Medical University
Location: Upstate Medical University Clinical Research Unit Syracuse New York
Summary
The goal of this observational study is to determine whether a clinically relevant dose of activated charcoal raises the serum osmolality and osmolal gap in a population of healthy volunteers. Secondarily to determine whether the same dose creates a false positive result using an enzymatic assay.
1. Does a clinically relevant dose of commercially available activated charcoal raise the osmolal gap above the baseline of a healthy volunteer?
2. Does the same dose of charcoal cause a false positive enzymatic assay for ethylene glycol?
Participants will be asked to consume a dose of activated charcoal and have serial blood draws for laboratory measurements.
Eligibility Criteria
Inclusion Criteria:
* Healthy adults
Exclusion Criteria:
* Any medical comorbidities
* Recent illness
* Pregnancy
* Prisoners
* Non-English speaking
* Weight \> 100 kg
Source: ClinicalTrials.gov (NCT07220031). StuddyBuddy aggregates publicly available trial information.
