Comparing Standard-Dose and High-Dose Cetirizine for Acute Urticaria

The goal of this clinical trial is to learn whether a higher dose of cetirizine works better than the standard dose to relieve symptoms of acute urticaria (hives) in adults. The study also aims to learn about the safety of taking a higher dose for a short period of time. The main questions the study aims to answer are: 1. Does the higher dose of cetirizine help people with acute urticaria improve faster than the standard dose? 2. What side effects do participants experience when taking the higher dose? Researchers will compare two groups: one group taking the standard dose of cetirizine (10 mg per day) and another group taking a higher dose (40 mg per day). This will help researchers understand which dose works better and whether the higher dose is safe. Participants will: Take the assigned study medication for 7 days Record their daily symptoms, including itch and hive severity Return for follow-up visits on Day 3, Day 7, and Week 6 Have blood tests to check liver and kidney function before and after treatment This study may help improve treatment options for people with acute urticaria and reduce the need for unnecessary steroid use.

Inclusion Criteria: * Adults aged 18 to 60 years * Clinical diagnosis of acute urticaria made by a physician * Onset of new wheals within the past 24 hours * Able and willing to comply with study procedures, complete symptom diaries, and attend follow-up visits * Provides written informed consent prior to participation Exclusion Criteria: * Use of systemic corticosteroids within the past 5 days * Use of immunosuppressive medications within the past 5 days * Clinical signs of anaphylaxis, including respiratory distress, hypotension, abdominal pain, or acute laryngeal swelling * Presence of angioedema without wheals * Known diagnosis of chronic urticaria * Known severe renal impairment (creatinine clearance \