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Completed
NCT07246681
Lignin in Treatment of Helicobacter Pylori Infection
Conditions: HELICOBACTER PYLORI INFECTIONS
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE3
Enrollment: 70
Sponsor: Zagazig University
Location: Kafrelsheikh University Kafr ash Shaykh Kafr el-Sheikh Governorate
Summary
The goal of this clinical trial is to learn if drug hydrolyzed lignin works to treat H pylori infection in adults. It will also learn about the safety of drug lignin n the sitting of H pylori infection, and if it halts the side effects associated with H pylori triple therapy. The main questions it aims to answer are:
* Does drug hydrolyzed lignin improve the H pylori eradiation rate when it is added to the standard triple therapy used in treatment of H pylori?
* What medical problems do participants experience when taking drug hydrolyzed lignin? Researchers will compare drug hydrolyzed lignin to a placebo (a look-alike substance that contains no drug) to see if drug hydrolyzed lignin works to treat H pylori.
Participants will:
* Take drug hydrolyzed lignin or a placebo every day for 2 weeks beside the standard triple therapy
* Visit the clinic once every 1 week for checkup and questionnaire filling
* Check for H pylori eradication after treatment
Eligibility Criteria
Inclusion Criteria:
* Age: Adults, older than 18.
* Gender: all
* Patient with confirmed diagnosis of H pylori for the first time
* H pylori treatment naive patients
* Welling to participate
Exclusion Criteria:
* Patients with failed H pylori eradication
* Allergy to the used medications
* Patients with other structural bowel diseases e.g. celiac disease, ischemic colitis, IBD, chronic diarrhea
* General debilitating diseases e.g. decompensated cirrhosis, renal failure
Source: ClinicalTrials.gov (NCT07246681). StuddyBuddy aggregates publicly available trial information.