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Completed
NCT07254715
Effect of Itopride on Semaglutide Gastroparesis
Conditions: Semaglutide-Induced Gastric Motility, Anesthesia
Sex: Female
Ages: 40 Years – 60 Years
Healthy volunteers: No
Phase: PHASE4
Enrollment: 60
Sponsor: Ain Shams University
Location: faculty of medicine, Ain Shams University Cairo
Summary
Semaglutide delays gastric emptying and increases the risk of aspiration with anesthesia; So, the addition of prokinetics as Itopride, could enhance gastric emptying and hasten surgery.
The investigator will evaluate the effect of Itopride on Semaglutide-induced gastroparesis and residual gastric contents after 8 hours of fasting by gastric ultrasound before anesthesia.
Eligibility Criteria
Inclusion Criteria:
* American Society of Anesthesiologists grade I- III.
* Age: 40-60 years.
* BMI: 20-30 kg/m2.
* Diabetic patients on semaglutide (0.5-1mg) SC weekly.
* Undergoing elective hysterectomy.
Exclusion Criteria:
* Declining to give written informed consent.
* history of upper abdominal surgery or the presence of hiatal hernia.
* Other medications inducing gastroparesis (opioids, proton pump inhibitors, tricyclic antidepressants, calcium channel blockers, antipsychotic medications, and lithium).
* History of allergy to Itopride.
* History of cardiac arrhythmia or abnormal ECG.
* Neurologic diseases (including Parkinson's disease and multiple sclerosis)
* Hepatic or renal failure.
Source: ClinicalTrials.gov (NCT07254715). StuddyBuddy aggregates publicly available trial information.
