The Effects of Coenzyme Q10 Pretreatment on Ovarian Function and Assisted Reproductive Outcomes in Patients With Ovarian Hyporesponsiveness.

Sex: Female

Ages: 20 Years – 39 Years

Healthy volunteers: No

Phase: NA

Enrollment: 128

Sponsor: Tang-Du Hospital

Summary

This prospective, randomized, double-blind, controlled study will be conducted at Tangdu Hospital, Air Force Medical University. It plans to enroll 128 patients with poor ovarian response for a 2-year study. The primary objective is to investigate the effects of exogenous coenzyme Q10 supplementation as pre-treatment on ovarian function and assisted reproductive clinical outcomes in patients with poor ovarian response. Study Hypothesis: Coenzyme Q10 therapy is expected to effectively enhance ovarian function and improve assisted reproductive outcomes in patients with poor ovarian response, while demonstrating favorable safety profiles.

Eligibility Criteria

Inclusion Criteria: * Individuals seeking IVF-ET fertility treatment; * Meeting the Bologna criteria for the definition of poor ovarian response (POR), specifically: * (1) Meeting 2 of the following 3 criteria: * ① Presence of high-risk factors for POR; * ② Previous cycle with ≤3 retrieved oocytes under a standard stimulation protocol; * ③ Abnormal ovarian reserve assessment: Antral follicle count (AFC) \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07260773). StuddyBuddy aggregates publicly available trial information.