Ablation With the PFA System With a Large-Area Focal Catheter for the Treatment of Persistent Atrial Fibrillation

The study evaluates the safety and effectiveness of the investigational QuickShot Nav configuration of the CardioWave System for focal catheter ablation of persistent atrial fibrillation (PerAF).

Inclusion Criteria: 1. Diagnosis of recurrent symptomatic paroxysmal AF (PAF) or persistent AF (PerAF) with the following documentation: Paroxysmal AF (Phase A participants) 1. Physician's note indicating symptoms consistent with recurrent symptomatic PAF AND 2. At least one documented episode of AF captured continuously on 12-lead ECG, or for at least 30 seconds on transtelephonic monitor (TTM), Holter monitor, telemetry strip, or similar within 12 months prior to enrollment Persistent AF (Phase A, B, and C participants) 1. Physician's note indicating symptoms consistent with recurrent symptomatic PerAF AND 2. Any 24-hour ECG recording of continuous AF within 12 months prior to enrollment OR 3. Two ECGs from any form of rhythm monitoring showing continuous AF taken at least 7 days apart within 12 months prior to enrollment OR 4. History of ≥2 direct current cardioversion (DCCV) performed within 12 months prior to enrollment 2. Failure or intolerance of at least one antiarrhythmic drug (AAD) (Class I - IV) for AF, as evidenced by recurrent symptomatic PerAF or intolerable side effects due to the AAD 3. Age 18 through 75 years-old on the day of enrollment 4. Patient is indicated for an ablation procedure according to society guidelines or study site practice 5. Patient is willing and able to give informed consent and is willing, able, and committed to participate in baseline and follow-up evaluations for the full duration of the study Exclusion Criteria: 1. Long-standing persistent AF (continuous AF sustained \> 1 year) 2. AF secondary to electrolyte imbalance, thyroid disease, alcohol abuse, or other reversible/non-cardiac causes 3. Prior cardiac ablation or surgical procedure (including left atrial appendage (LAA) device or occlusion, or valvular cardiac procedure) 4. Planned LAA closure procedure or implant of a permanent pacemaker, biventricular pacemaker, or any type of implantable cardiac defibrillator (with or without biventricular pacing function) for any time during study participation 5. Presence of any permanent pacemaker, biventricular pacemaker, or implantable cardiac defibrillator (with or without biventricular pacing function) that cannot be programmed, per the manufacturer's recommendations, during the ablation procedure 6. Patient cannot be removed from AADs for reasons other than AF, which includes participants with Wolff-Parkinson-White (WPW) Syndrome and participants with a history of ventricular tachycardia (VT) 7. Presence of any IVC filters 8. Presence of an interatrial baffle or patch 9. Presence of any pulmonary vein stents 10. Pre-existing pulmonary vein stenosis 11. Pre-existing hemidiaphragmatic paralysis 12. Atrial or ventricular septal defect closure 13. Atrial myxoma 14. Presence of any mechanical or biologic prosthetic heart valve 15. Hemodynamically significant valvular disease as determined by the Investigator 16. History of pericarditis 17. History of Rheumatic heart disease 18. History of thromboembolic event within 6 months prior to Index Ablation Procedure or evidence of intracardiac thrombus at time of the Index Ablation Procedure 19. Any of the following events within 3 months prior to the Index Ablation Procedure: * Myocardial infarction * Unstable angina * Percutaneous coronary intervention * Heart surgery including coronary artery bypass grafting * Heart failure hospitalization * Cerebral ischemic event (stroke or transient ischemic attack (TIA)) * Clinically significant bleeding requiring surgical intervention * Pericardial effusion * Ventriculotomy or atriotomy 20. New York Heart Association (NYHA) Class IV congestive heart failure 21. Documented left ventricular ejection fraction (LVEF) ≤35% measured by acceptable cardiac testing (e.g., TTE, cardiac CT, etc.) within 6 months prior to enrollment 22. Hypertrophic cardiomyopathy 23. Primary pulmonary hypertension 24. Significant or symptomatic hypotension 25. Thrombocytosis, thrombocytopenia 26. Contraindication to, or unwillingness to use, systemic anticoagulation 27. Patient contraindicated for CT or MRI 28. Sensitivity to contrast media not controlled by premedication 29. Women known to be pregnant or breastfeeding, or any women of childbearing potential who are not on a reliable form of birth regulation method or abstinence 30. Patient is participating in any other potentially confounding research 31. Serious or untreated medical conditions that would prevent participation in the study, interfere with assessment or therapy, or confound data or is interpretation, including but not limited to: * Solid organ or hematologic transplant, or currently being evaluated for organ transplant * Severe lung disease, pulmonary hypertension, or any lung disease involving abnormal blood gases or significant dyspnea * Chronic renal insufficiency with eGFR \