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Enrolling By Invitation
NCT07298993
Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF)
Conditions: Heart Failure, HFpEF, HFpEF - Heart Failure With Preserved Ejection Fraction
Sex: All
Ages: 60 Years – N/A
Healthy volunteers: No
Phase: PHASE4
Enrollment: 240
Sponsor: Weill Medical College of Cornell University
Location: Kaiser Permanente Northern California (KPNC) Pleasanton California
Summary
The goal of this study is to learn whether stopping beta-blockers can help older adults with heart failure with preserved ejection fraction (HFpEF) feel better and function better. This study will test whether "deprescribing" or stopping these medications in a careful, guided way can improve symptoms and quality of life.
Participants will be randomly assigned to one of two groups:
Deprescribing group: Beta-blockers are gradually reduced using capsules that contain decreasing doses.
Usual care group: Beta-blockers are continued at the usual dose in look-alike capsules.
All participants will:
* Take study medicine for about 4 months
* Have their blood pressure and heart rate monitored
* Complete regular phone calls and questionnaires about how they are feeling
This study does not involve any experimental medication. Participants active involvement in the study will last approximately 4 months. During these 4 months they will have 8 scheduled telephone visits.
Eligibility Criteria
Inclusion Criteria:
1. Ambulatory adults age ≥60 years with HFpEF (EF ≥50% based on most recent transthoracic echocardiogram)
2. Hospitalized with HF in the past 24 months (defined by diagnostic codes in any position)
3. Taking any of the following ß-blockers: atenolol, bisoprolol, carvedilol, metoprolol succinate, or metoprolol tartrate (i.e., pharmacy prescription data)
4. Kaiser Permanence Northern California Membership
Exclusion Criteria:
1. Alternative etiologies of HFpEF syndrome
2. Compelling guideline indication for ß-blocker:
* Prior EF \
Source: ClinicalTrials.gov (NCT07298993). StuddyBuddy aggregates publicly available trial information.