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NCT07306078
Methylphenidate and Response to Alcohol Cues
Conditions: Alcohol Use Disorder
Sex: All
Ages: 18 Years – 25 Years
Healthy volunteers: Yes
Phase: PHASE2
Enrollment: 50
Sponsor: University of Florida
Location: University of Florida Gainesville Florida
Summary
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues. The study will observe the effects of methylphenidate or a placebo on neural and craving responses to alcohol cues through fMRI and behavioral testing. Participants will be involved in one remote and two in-person sessions.
Eligibility Criteria
Inclusion Criteria:
* Adults ages 18-25 years
* Meets DSM-5 criteria for Alcohol Use Disorder -OR- score on the Alcohol Use Disorders Identification Test (AUDIT) of \>=8
* Fluent in English
* Normal or corrected to normal vision
Exclusion Criteria:
* Meets DSM-5 criteria for psychotic disorders, neurological disorders, or substance use disorders other than Alcohol Use Disorder.
* Participant routinely uses psychoactive drugs or medications except for non-dependent marijuana or nicotine use (due to common use of these substances in individuals with Alcohol Use Disorder).
* Participant has contraindications for taking methylphenidate.
* Participant has contraindications for being in an MRI machine
* Self-reported history of high blood pressure over 140/90 or consistent readings of 140/90 or above upon arrival for a session.
* History of seizure disorder
* Liver disease
* Participant is currently pregnant or trying to become pregnant
Source: ClinicalTrials.gov (NCT07306078). StuddyBuddy aggregates publicly available trial information.