Exploring Resistance Exercise Training Plus High-Intensity Interval Training (ReHIIT) as Cancer Prehabilitation

Colorectal cancer is the fourth most common cancer in the UK. Prehabilitation, including exercise, can improve recovery from surgery. This pilot study investigates the combined effects of resistance and high-intensity interval training (ReHIIT) in healthy adults to establish baseline physiology and responses for comparison with cancer patients

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Availability and willingness to attend the Royal Derby Hospital site for a minimum of 8 exercise sessions and 2 assessment sessions across the study period. Exclusion Criteria: * BMI \35 kg/m2 * Known active cance * Known metabolic disease * Current known neurological or musculoskeletal conditions (e.g. epilepsy) * Active known cardiovascular, cerebrovascular or respiratory disease - e.g: * Uncontrolled hypertension (systolic BP \> 160 mmHg or diastolic BP \>100 mmhg) * Myocardial infarction within the last 6 months or unstable angina * Heart failure (New York Heart association Class III/IV) * Arrhythmia * Right to left cardiac shunt * Aneurysm of a named blood vessel * COPD * Pulmonary hypertension * Exercise-induced or brittle asthma * Previous stroke/transient ischaemic attack * Abnormal ECG results (at the discrepancy of the study doctor) * Patients who are unable to undergo CPET based on ATS/ACSS guidelines \^ * Pre-existing clotting disorder known to the participant or anticoagulant use * Family history of severe bleeding requiring medical intervention * Participation in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (ALL UoN FMHS UREC approved studies) * Pregnant or breastfeeding