Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU

This observational study compares extended versus intermittent beta-lactam infusion in sepsis patients, assessing survival, clinical cure rates, and practical ICU challenges. The findings will guide optimal antibiotic protocols, potentially improving sepsis outcomes through precision dosing strategies.

Inclusion Criteria: * Aged: 18 - 65 * Patients admitted to critical care unit diagnosed with pneumonia with two of the following: 1. Temperature: over 38 degree celsius 2. Heart rate: over 100 beats per minute 3. Respiratory rate: over 20 breaths per minute 4. leucocyte count over than 12000 or less than 4000 microlitres or over 10% immature forms or bands * Patients with positive sputum Exclusion Criteria: * Hypersensitivity to Beta-lactams * Pregnancy * Very low probability of survival using APAACHE II score \> 34 points. * Immunodeficency or taking immunosuppressive medications * Acute or chronic renal failure with creatinine clearance less than 30 ml/min according to Cockcroft-Gault formula.