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Completed
NCT07414056
Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predictors of ARDS in Pediatric Burn Patients: A Prospective Evaluation
Conditions: Acute Respiratory Distress Syndrome (ARDS)
Sex: All
Ages: 1 Year – 12 Years
Healthy volunteers: No
Enrollment: 60
Sponsor: Ain Shams University
Location: Ain Shams University Cairo
Summary
The aim of this study is to evaluate the role of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as predictors for development of ARDS in pediatric burn patients.
Eligibility Criteria
Inclusion Criteria:
* Age 1-12 years.
* Patients presenting within 24 hours of burn injury.
* Patients presenting with severe burns 20-40% of total body surface area (TBSA).
* Thermal burns or scalds.
* Both sexes.
Exclusion Criteria:
* Patient refusal to participate in the trial.
* Age \12 years.
* Delayed admission \>24h post-injury.
* Patients presenting with burns \40% of TBSA.
* Non-thermal burns.
* Associated medical comorbidities: Chronic liver or kidney diseases, anemia.
* Preexisting chronic lung disease (e.g., cystic fibrosis, severe bronchopulmonary dysplasia).
* Inflammatory conditions (e.g., inflammatory bowel disease).
* Immunocompromised individuals, autoimmune diseases, those undergoing treatment with immunosuppressants, corticosteroids, cytotoxic chemotherapy.
* Known malignancies, hematologic malignancy or conditions altering WBC/platelets significantly.
* Previous malnutrition.
* Immunosuppressive therapy prior to admission (e.g., chronic steroids).
Source: ClinicalTrials.gov (NCT07414056). StuddyBuddy aggregates publicly available trial information.