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NCT07415876
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA
Conditions: Kidney Transplant Rejection
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 50
Sponsor: Virginia Commonwealth University
Location: Virginia Commonwealth University Richmond Virginia
Summary
Kidney transplant rejection remains a significant challenge to long-term graft survival. While histological biopsy continues to be the gold standard for diagnosing rejection, noninvasive biomarkers such as donor-derived cell-free DNA (dd-cfDNA) have gained traction for their ability to detect allograft injury. However, dd-cfDNA may lack sensitivity in certain clinical scenarios particularly in cases of localized immune activation leading to false negatives despite biopsy-confirmed rejection.
Eligibility Criteria
Prospective Inclusion Criteria:
* Age ≥18 years
* Undergoing a clinically indicated biopsy
* Able to provide informed consent
* Willing to provide a urine sample and allow access to relevant clinical
Retrospective Inclusion Criteria:
* Age ≥18 years
* Biopsy-confirmed rejection (positive histology)
* Donor-derived cell-free DNA\
Source: ClinicalTrials.gov (NCT07415876). StuddyBuddy aggregates publicly available trial information.
