Multisensor Wireless Pressure Microcatheter For Microvascular Function Assessment In ANOCA/INOCA Patients: A Prospective, Multicenter, Single-Group Target Value Study

This study aims to evaluate the sensitivity and specificity of a multi-sensor wireless pressure microcatheter for the diagnosis of CMD in patients with ANOCA/INOCA, using quantitative myocardial perfusion imaging of cardiac magnetic resonance (CMR) as a reference.

Inclusion Criteria: 1. Age ≥ 18 years, gender not limited; 2. Symptoms of angina pectoris, or objective evidence of myocardial ischemia (e.g., electrocardiogram, myocardial injury markers, etc.); 3. Visual assessment of coronary angiography shows diameter stenosis \< 50% and FFR \> 0.8 (or cRR \> 0.89); 4. Microvascular function assessment is planned; 5. Agree to participate in this clinical study and voluntarily sign the informed consent form. Exclusion Criteria: 1. Acute myocardial infarction, PCI, CABG, or valvular surgery following angiography within the past 30 days; 2. Severe valvular disease requiring surgical or interventional treatment; 3. Chest pain with known non-ischemic causes (e.g., pericarditis, pulmonary hypertension, esophageal spasm); 4. Contraindications to CMR (e.g., certain types of pacemakers or defibrillators, severe claustrophobia); 5. Clear contraindications to adenosine and ATP use (e.g., second- or third-degree atrioventricular block, sick sinus syndrome, severe asthma, systolic blood pressure below 90 mmHg); 6. Renal insufficiency (eGFR ≤ 45 mL/min/1.73 m2) or currently undergoing dialysis; 7. Severe heart failure or LVEF ≤ 35%; 8. Severe organ disease or life expectancy less than 2 years; 9. Known to be participating in other drug or device clinical trials that have not yet met the primary endpoint; 10. Other investigators deem the candidate unsuitable for this clinical trial.