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NCT07462702
Topical Minocycline for CARP
Conditions: Confluent and Reticulated Papillomatosis (CARP)
Sex: All
Ages: 9 Years – N/A
Healthy volunteers: No
Phase: EARLY_PHASE1
Enrollment: 35
Sponsor: Medical University of South Carolina
Summary
This proof-of-concept trial evaluates the efficacy, safety, and patient satisfaction of topical minocycline foam (AMZEEQ®) in patients aged 9 and older with confluent and reticulated papillomatosis (CARP). Participants will apply AMZEEQ® to one side of the body and a topical emollient to the other for 5 weeks, followed by an optional extension period. The study aims to assess whether topical minocycline is a well-tolerated and effective alternative to oral antibiotics.
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 9 years
* Clinical diagnosis of CARP
Exclusion Criteria:
* Current or recent (within 6 months) use of oral minocycline
* Pregnancy or breastfeeding
* History of intracranial hypertension, autoimmune disorder, liver/kidney disease
* Immunocompromised status
* Hypersensitivity to tetracyclines
* Unstable medical condition
* Inability or unwillingness to provide informed consent
Source: ClinicalTrials.gov (NCT07462702). StuddyBuddy aggregates publicly available trial information.
