Surgical Glove Compression to Prevent Paclitaxel Neuropathy

Conditions: Paclitaxel-Induced Peripheral Neuropathy, Breast Cancer, Surgical Glove

Sex: Female

Ages: 18 Years – 80 Years

Healthy volunteers: No

Phase: NA

Enrollment: 84

Sponsor: Necmettin Erbakan University

Location: Necmettin Erbakan University, Faculty of Health Sciences Konya Meram

Summary

This study aims to evaluate the effect of surgical glove compression as a prophylactic method to prevent paclitaxel-induced peripheral neuropathy. Participants will be randomly assigned to two groups: one receiving standard care, and the other receiving prophylactic surgical glove compression. The study will compare the development, severity of neuropathy in the hands and fingers, and its impact on quality of life.

Eligibility Criteria

Inclusion Criteria: * Patients aged between 18 and 80 years * Diagnosed with Stage II-III breast cancer * No distant metastasis * Planned to receive adjuvant or neoadjuvant paclitaxel for at least 12 weeks * Willing and able to provide informed consent * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 Karnofsky ≥ 60%) Exclusion Criteria: * Recurrent breast cancer * Prior treatment associated with neuropathy (e.g., taxanes, platinum-based chemotherapy, anti-tubulin or proteasome inhibitors)

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07504770). StuddyBuddy aggregates publicly available trial information.