Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada

Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated exposure contributes to long-term lung disease. This study is a controlled human exposure to varying concentrations of WFS in a safe setting. By comparing the effects of different concentrations, this research will improve understanding of health impacts, identify who may be most vulnerable to exposures, and explore biological changes that could lead to chronic illness.

Inclusion Criteria: * Healthy Adults between the ages of 19 to 80 (12 of each biological sex assigned at birth). Exclusion Criteria: 1. Current smoker (within six months before screening; potential to confound exposure effects). 2. History or current diagnosis of any respiratory conditions (including, but not limited to asthma or chronic obstructive pulmonary disease (COPD), asthma/COPD overlap) or other medical conditions that the study physician determines may impact participant safety. 3. Any comorbidities or other concerns identified by the study physician which may impact study participation. 4. For participants of child-bearing potential: Current pregnancy, or plans to become pregnant during study enrolment.