Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?

After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and bacteria may affect healing. This study will investigate how different collagen-based biomaterials behave when exposed in the mouth, evaluating healing, bone changes, bacterial contamination, and patient experience. Sixty patients will be included in a randomized clinical trial comparing two commonly used biomaterials and natural healing. The results will help clinicians choose safer and more effective treatments, improving outcomes for patients undergoing tooth extraction and future implant rehabilitation.

Inclusion Criteria: * Adult subjects in need of non-molar maxillary or mandibular single tooth extraction at the PUCRS university - Porto Alegre - Brazil. 1. \> 18 years of age 2. non-molar tooth indicated for extraction 3. intact sockets upon extractions 4. Patients using removable provisional prosthesis (accessible to remove possible contact with surgical site) or patients without prosthesis after tooth extraction. Exclusion Criteria: 1. Current smokers 2. Uncontrolled Diabetes Mellitus 3. Mandibular incisors 4. Patients receiving chemo or radiotherapy or history of these treatments in the previous 5 years 5. Any other disease or medications that may compromise normal wound healing 6. Unwilling or unable to sing the informed consent