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Completed
NCT07598994
Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain
Conditions: Temporomandibular Disorders (TMD), Temporomandibular Pain
Sex: Female
Ages: 18 Years – 65 Years
Healthy volunteers: No
Phase: NA
Enrollment: 50
Sponsor: Istanbul University
Location: Istanbul University Faculty of Dentistry Istanbul Istanbul
Summary
The goal of this clinical trial is to compare the effectiveness and safety of topical capsaicin cream and topical diclofenac gel in women with chronic temporomandibular joint-related pain. The main questions it aims to answer are:
* Does topical capsaicin reduce pain intensity more effectively than topical diclofenac?
* Do the treatments improve jaw function, pressure pain threshold, and neuropathic pain symptoms?
Researchers will compare topical capsaicin cream with topical diclofenac gel to evaluate differences in pain relief and functional improvement.
Participants will:
* Apply the assigned topical medication four times daily for 7 days
* Attend clinical examinations and pain assessments at baseline, Day 8, and Month 1
* Complete pain-related questionnaires and functional jaw measurements during follow-up visits
Eligibility Criteria
Inclusion Criteria:
* Female participants aged between 18 and 65 years
* Diagnosis of temporomandibular disorder (TMD)-related pain
* Presence of pain for at least 3 months
* Baseline pain intensity sufficient to require treatment
* Willingness to comply with study procedures and follow-up visits
* Signed informed consent form
Exclusion Criteria:
* Pregnancy or breastfeeding
* History of allergy or hypersensitivity to capsaicin or diclofenac
* Presence of systemic inflammatory or neurological disease
* Use of systemic analgesics, corticosteroids, or muscle relaxants during the study period
* Active skin lesions or dermatologic disease in the application area
* Previous temporomandibular joint surgery
* Participation in another clinical trial within the last 30 days
* Inability to comply with study procedures
Source: ClinicalTrials.gov (NCT07598994). StuddyBuddy aggregates publicly available trial information.