A Pilot Study: Micro and NanoPlastics in Association With Crohn's Disease

Micro and nanoplastics (MNPs) are environmental contaminants found in food and water. Recent evidence suggests these particles may be linked to intestinal inflammation and changes in gut bacteria, which are key features of Crohn's Disease (CD). This study aims to investigate if patients with Crohn's Disease have a reduced ability to clear these plastic particles and how this affects their immune system and intestinal health.

Inclusion Criteria: Cases: * Age 18-80 years * Confirmed diagnosis of Crohn's disease (for cases) * Ability to provide informed consent. Control: * Age 18-80 years old * No history of major large bowel resection * Ability to provide informed consent. Exclusion Criteria: Cases: * Antibiotic/probiotic use within 4 weeks * History of gastrointestinal malignancy * Presence of stoma * Currently Pregnant * Advanced terminal medical illness, e.g. terminal malignancies; end staged renal failure and liver failure Control: * Currently Pregnant * Advanced terminal medical illness, e.g. terminal malignancies; end staged renal failure and liver failure * Inability in giving consent