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Recruiting
NCT07635238
A Study of Lower Dose Radiation Therapy for People With Prostate Cancer
Conditions: Prostate Cancer, Prostate Adenocarcinoma
Sex: Male
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE2
Enrollment: 54
Sponsor: Memorial Sloan Kettering Cancer Center
Location: Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) Basking Ridge New Jersey
Summary
The purpose of this study is to see whether giving a lower (de-escalated) dose of radiation therapy to some parts of the prostate can reduce side effects compared to giving the same (uniform) dose of radiation therapy to the whole prostate.
Eligibility Criteria
Inclusion Criteria:
* Documentation of Disease
o Patients must have pathologically confirmed prostate adenocarcinoma.
* Definition of Disease
* Grade Group (GG) 1, 2, or 3.
* PSA less than 20 ng/mL prior to starting ADT, if used.
* Clinical stage of TX, T1 or T2 on digital rectal examination. May have up to radiological stage T3a on MRI. MRI must be performed within 12 months of randomization.
* MRI-visible tumor(s), all having PIRADS v2.1 scores of 3, 4, or 5. Each tumor should be able to be delineated on T2 and diffusion-weighted imaging (DWI) +/- dynamic contrast-enhanced imaging (DCE).
* Tumor nodule visible on MRI should be considered able to be boosted by treating clinician (ie meet urethral constraints while maintaining mandatory GTV coverage) and \
Source: ClinicalTrials.gov (NCT07635238). StuddyBuddy aggregates publicly available trial information.
