Late-Onset Neonatal Sepsis: A Case-Control Study

The diagnosis of late-onset sepsis in term neonates has been studied less than that of early-onset sepsis. Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers in the diagnosis of sepsis. However, their diagnostic advantage for late-onset sepsis (GNS) is debatable. Rapid and accurate diagnosis of late-onset infection in newborn infants remains a significant goal in clinical practice worldwide. Therefore, the accuracy of diagnostic tests needs to be improved. This study aimed to evaluate the effectiveness of serum biomarkers in the diagnosis and treatment monitoring of late neonatal sepsis (LOS) in term neonates.

Inclusion Criteria: * Term newborn * Late-onset neonatal sepsis Exclusion Criteria: * Preterm newborn * Major congenital anomaly * Congenital metabolic disease * Hemolytic anemia * Hematological diseases * Congenital leukemia * Dyserythropoietic anemia * Early-onset neonatal sepsis Control group * Neonatal jaundice (indirect hyperbilirubinemia) * Transient neonatal tachypnea * Early neonatal sepsis Exclusion criteria Perinatal asphyxia, Meconium aspiration syndrome Polycythemia İntraventricular hemoragy Pneumothorax Hemolytic Anemia