Impacts of HIV Treatment Regimens on Archived Drug Resistance

Conditions: HIV -1 Infection, Antiretroviral Therapy, Drug Resistance, Microbial

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 420

Sponsor: Chinese University of Hong Kong

Location: S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong Hong Kong Hong Kong

Summary

The study aims to determine the prevalence of drug resistance mutation (DRM) in virally suppressed HIV infection, and the impacts of regimen change and the presence of low level viremia. Adults living with HIV infection on antiretroviral therapy (ART) with full viral suppression would be recruited. Cases are patients planning for regimen switch, while controls are those with and without low level viraemia (LLV) not planned for switch. Blood samples would be collected before and after switch. Sequencing would be performed to identify DRM present in HIV-1 proviral DNA.

Eligibility Criteria

Inclusion Criteria: * Patients living with HIV who are (a) aged 18 or above, (b) on antiretroviral therapy, (c) has viral load \

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07643948). StuddyBuddy aggregates publicly available trial information.