Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery

Conditions: Impacted Third Molar, Postoperative Pain, Neuroinflammation, Anxiety

Sex: All

Ages: 18 Years – 38 Years

Healthy volunteers: Yes

Phase: NA

Enrollment: 40

Sponsor: Plovdiv Medical University

Summary

A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval. Serum kynurenic acid (KYNA) and serotonin were measured preoperatively and 24 hours after each procedure. The study examined longitudinal dynamics of kynurenine pathway biomarkers, their variation across Pederson surgical difficulty grades, and their relationship with postoperative pain and state anxiety.

Eligibility Criteria

Inclusion Criteria: * Bilateral impacted mandibular third molars requiring surgical extraction * Age 18-38 years * Written informed consent * Ability to comply with study procedures Exclusion Criteria: * Systemic inflammatory disease * Autoimmune disease * Neurological disease * Psychiatric disorders * Chronic pain conditions * Use of immunomodulatory medications * Use of psychotropic medications * Use of analgesic medications * Pregnancy * Drug hypersensitivity * Active pericoronitis at enrollment

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07644065). StuddyBuddy aggregates publicly available trial information.