Join us at Health Research Day — June 6th at Canton Waterfront Park, Baltimore!   Learn More →
← Back to all trials
Completed NCT07653191

Changes in Uterine Artery Resistance Index Following Cervical Conization

Conditions: Cervical Intraepithelial Neoplasia, Uterine Artery Hemodynamics

Sex: Female
Ages: 30 Years – 50 Years
Healthy volunteers: No
Phase: NA
Enrollment: 50
Sponsor: Adana City Training and Research Hospital

Location: Adana City Training and Research Hospital Adana

Summary

The objective of this prospective study is to evaluate the hemodynamic impact of cervical conization on uterine artery blood flow by focusing on the Resistance Index (RI) as a direct indicator of distal vascular resistance. The central hypothesis is predicated on the physiological principle that the surgical excision and subsequent sealing of terminal cervical branches during conization increases the distal vascular impedance (afterload) encountered by the main uterine artery. Uterine artery Doppler RI measurements are performed preoperatively and at one month postoperatively to assess these alterations.

Eligibility Criteria

Inclusion Criteria: 1. Regularly menstruating female patients aged between 30 and 50 years. 2. Definitive clinical indication for cervical conization based on abnormal cervical cytology, positive HPV screening, or colposcopy-guided biopsy findings. Exclusion Criteria: 1. Concomitant pelvic pathologies that could independently alter uterine artery blood flow or Doppler indices, such as uterine fibroids, ovarian cysts, endometriosis, pelvic inflammatory disease (PID), or hydrosalpinx. 2. Acute postoperative bleeding complications.

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07653191). StuddyBuddy aggregates publicly available trial information.