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NCT07653464
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Conditions: Obesity (BMI>30), Insulin Resistance
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: EARLY_PHASE1
Enrollment: 64
Sponsor: University of Missouri-Columbia
Location: University of Missouri Columbia Missouri
Summary
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Eligibility Criteria
Inclusion Criteria:
* 18 to 65 years of age
Individuals with obesity and comorbid IR
* BMI 30-45 kg/m2
* Waist circumference ≥102 cm (men) or ≥88 cm (women)
* HOMA-IR ≥2.5
Healthy normal weight adults
* BMI 18-25 kg/m2
* Waist circumference \10% within the last 6 months
* Adherence to \>150 min/week of moderate-to-vigorous physical activity/exercise
* Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
* Claustrophobia
* Non-MRI compatible metal implants
Source: ClinicalTrials.gov (NCT07653464). StuddyBuddy aggregates publicly available trial information.
