Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients.

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Phase: PHASE4

Enrollment: 100

Sponsor: Helwan University

Summary

A randomozed control trial on adults who underwent orthopaedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in the orthopaedic surgical population. Eligible patients will be randomized using block randomization into 2 groups: intervention group and control group. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).

Eligibility Criteria

Inclusion Criteria: * Orthopaedic surgical ward patients who underwent major surgery. Exclusion Criteria: * Patients who require reoperation within 30 days. * Immunosuppressant patients. * Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively. * Pregnancy or breastfeeding.

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07655596). StuddyBuddy aggregates publicly available trial information.