Effects of Acetyl L-Carnitine Supplementation on Clinical, Metabolic and Inflammatory Symptoms in Obese, Diabetic, Postmenopausal Women With Osteoarthritis

OA is a degenerative bone disease more common in postmenopausal women. Diabetes and obesity are common risk factors for the development of OA. The common symptoms include pain and disability of the affected joint, leading to mobility issues. Acetyl L-carnitine due to its known anti-inflammatory, chondroprotective, and improved insulin-sensitizing effects may help in alleviating the symptoms and progression of OA in obese diabetic postmenopausal women.

Inclusion Criteria: 1. Age 55-65 years 2. Duration of menopause 2-15 years. 3. Duration of diabetes 5-15 years 4. BMI Obese ≥30 kg/m2 5. Grade≥2 K\&L on radiologic examination Exclusion Criteria: * Female patients with osteoarthritis meeting the following criteria will be excluded from the study; 1. Age˂55 ˃65yrs 2. Post-menopausal duration of ˂2yrs 3. Duration of diabetes ˂ 5years 4. Patients with alcohol abuse, asthma, cardiac disease, chronic gastric problems (malabsorption, crohn's disease chronic diarrhea), non-diabetes related renal disease,ovariectomy, rheumatoid arthritis or other rheumatic inflammatory diseases, smoking 5. Patients taking steroids (oral/ injections) 6. Patients with a history of parathyroid and thyroid surgery/dysfunction