Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients

Sex: All

Ages: 18 Years – 65 Years

Healthy volunteers: Yes

Phase: NA

Enrollment: 90

Sponsor: Gaziantep City Hospital

Location: Marmara University Faculty of Medicine Pendik Training and Research Hospital Istanbul Istanbul

Summary

Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial. This prospective randomized study aimed to compare the effects of low-flow sevoflurane anesthesia, normal-flow sevoflurane anesthesia, and total intravenous anesthesia (TIVA) on postoperative cognitive function and recovery characteristics in obese patients undergoing elective laparoscopic abdominal surgery. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) before surgery, at postoperative 30 minutes, and on postoperative day 3.

Eligibility Criteria

Inclusion Criteria: * Age between 18 and 65 years * Body mass index (BMI) ≥30 kg/m² * ASA physical status I-III * Scheduled for elective laparoscopic abdominal surgery * Provision of written informed consent Exclusion Criteria: * History of psychiatric disease * Dementia or known cognitive impairment * Hearing or language disorders preventing MMSE assessment * Refusal to participate * Conversion from laparoscopic to open surgery

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07665645). StuddyBuddy aggregates publicly available trial information.