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NCT07668505
Anti-inflammation Treatment for Idiopathic Inflammatory Myopathies
Conditions: Myositis
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: No
Phase: PHASE4
Enrollment: 10
Sponsor: Chinese University of Hong Kong
Location: Prince of Wales hospital Hong Kong
Summary
The goal of this clinical trial is to learn if the drug Maraviroc works to treat refractory idiopathic inflammatory myopathy (myositis) in patients who have not responded well to traditional therapies. It will also learn about how the drug affects muscle inflammation and function.
The main questions it aims to answer are:
Does Maraviroc reduce inflammation in the muscles?
Does Maraviroc improve patients' muscle function and overall clinical symptoms?
This is an open-label study, meaning researchers will give Maraviroc to all participants (there is no placebo) to see if the drug works to treat refractory myositis.
Participants will:
Take a 300mg Maraviroc tablet every day for 12 weeks
Undergo exams and tests with their doctors to check their muscle function, symptom improvement, and specific health markers (like enzyme levels)
Eligibility Criteria
Inclusion Criteria:
1. ≥18 to \18 years
3. fulfillment of 2017 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) IIM classification criteria
4. active myositis defined as Manual Muscle Testing 8 (MMT8) score \
Source: ClinicalTrials.gov (NCT07668505). StuddyBuddy aggregates publicly available trial information.