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Not Yet Recruiting NCT07686120

A Phase IIIb Study to Investigate the Effect of Baxdrostat in Chinese Participants With Uncontrolled Hypertension.

Conditions: Uncontrolled Hypertension

Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE3
Enrollment: 286
Sponsor: AstraZeneca

Summary

This is a Phase IIIb, multicentre, randomised, double-blind, placebo-controlled, parallel group study to evaluate the effect of baxdrostat 2mg versus placebo, administered QD orally, on the reduction of ambulatory 24-hour average SBP in participants with uHTN. Consenting participants will be screened within 4 weeks and will subsequently enter a 4-week run-in period with placebo. Thereafter, participants will be randomised in a 1:1 ratio to receive one of the following 2 treatments QD, during a 12-week double-blind treatment period: baxdrostat 2mg Placebo The randomisation will be stratified by mean ambulatory SBP at baseline (\

Eligibility Criteria

Inclusion Criteria: Participants are eligible to be included in the study only if all of the following criteria apply: Age 1. Participant must be ≥18 years old, at the time of signing the informed consent. Type of Participant and Disease Characteristics 1. Mean seated SBP on AOBPM ≥140 mmHg and \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07686120). StuddyBuddy aggregates publicly available trial information.