C-PRF With Minimally Invasive Non-Surgical Periodontal Therapy

This randomized controlled clinical study evaluated whether concentrated platelet-rich fibrin (C-PRF) provides additional clinical and radiographic benefits when used together with minimally invasive non-surgical periodontal treatment (MINST) in patients with advanced periodontitis and intrabony periodontal defects. Thirty systemically healthy patients with stage III-IV periodontitis were included. Each participant had at least one intrabony defect with a probing pocket depth of 6 mm or greater and a radiographic intrabony component of 3 mm or greater. Participants were randomly assigned to receive either MINST alone or MINST combined with C-PRF application. Clinical periodontal measurements, including probing pocket depth, clinical attachment level, plaque score, bleeding on probing, and gingival recession, were recorded at baseline and at the 6-month follow-up. Standardized periapical radiographs were used to evaluate radiographic outcomes, including total defect depth, intrabony defect depth, defect angle, and linear bone fill.

Inclusion Criteria: * Individuals aged 18 to 70 years. * Systemically healthy individuals. * Individuals diagnosed with Stage III or Stage IV periodontitis. * Presence of at least one periodontal intrabony defect with a radiographic intrabony defect depth of ≥3 mm. * Presence of probing pocket depth of ≥6 mm at the selected defect site. * No periapical pathology associated with the selected tooth. Exclusion Criteria: * Pregnancy or lactation. * Presence of systemic diseases or use of medications that may affect periodontal healing. * Periodontal treatment within the recent period before enrollment. * Smoking ≥10 cigarettes per day. * Presence of periapical pathology associated with the selected tooth.