Endovascular Treatment of Chronic Intracranial Artery Occlusion

Comparison of the efficacy and safety of endovascular treatment versus medical treatment in patients with chronic intracranial artery occlusion.

Inclusion Criteria: 1. Age ≥18 years 2. Occlusion of the unilateral middle cerebral artery, basilar artery, intracranial internal carotid artery, or vertebral artery, as confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA) 3. Modified Rankin Scale (mRS) score of 0-2 4. Presence of symptoms related to the occluded vessel, as determined by the physician, with the most recent symptom onset occurring more than 4 weeks and within 6 months prior to enrolment 5. The subject or their legally authorised representative has provided written informed consent for the study Exclusion Criteria: 1. Evidence of hemorrhage on CT or MRI 2. Large hemispheric infarction involving \>50% of the middle cerebral artery territory on CT or MRI 3. Severe pre-stroke disability (modified Rankin Scale score ≥2) or life expectancy \120 mmHg) 8. Known inherited or acquired bleeding diathesis, coagulation factor deficiency, or recent oral anticoagulant therapy with an international normalized ratio (INR) \>3 9. Suspected septic emboli or suspected bacterial endocarditis 10. Known allergy to iodine, heparin, or anaesthetics, or other definite contraindications to endovascular procedures 11. Pregnant women 12. Other severe, progressive, or terminal diseases (as judged by the investigator), or life expectancy \