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NCT07699133
Effect of Controlled Hypotension on GFAP and Cognition in Rhinoplasty
Conditions: Nasal Septum Deviation, Rhinoplasty, Induced Hypotension
Sex: All
Ages: 18 Years – 50 Years
Healthy volunteers: No
Enrollment: 40
Sponsor: Kahramanmaras Sutcu Imam University
Summary
This prospective observational study aims to evaluate the neurological safety of controlled hypotension (Mean Arterial Pressure 50-65 mmHg) during elective rhinoplasty. The investigators will assess whether this standard intraoperative hypotensive strategy causes cellular stress by measuring serum Glial Fibrillary Acidic Protein (GFAP) levels and early postoperative cognitive changes using the Montreal Cognitive Assessment (MoCA) test.
Eligibility Criteria
Inclusion Criteria:
* Scheduled for elective rhinoplasty or septorhinoplasty under general anesthesia.
* ASA physical status I or II.
* Literate and willing to provide written informed consent.
Exclusion Criteria:
* History of neurological (e.g., cerebrovascular event, epilepsy) or psychiatric diseases.
* Total septal reconstruction requiring costal (rib) cartilage grafts.
* Expected surgical duration exceeding 3 hours.
* Preoperative severe cognitive impairment.
* Pregnancy or lactation.
Source: ClinicalTrials.gov (NCT07699133). StuddyBuddy aggregates publicly available trial information.
