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NCT07701512
Clinical Study to Evaluate the Efficacy of Febuxostat in the Treatment of Conservatively Managed Intracranial Hemorrhage Patients
Conditions: Intracranial Hemorrhage
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE2
Enrollment: 46
Sponsor: Tanta University
Location: Neurosurgery department Mansoura university hospitals Al Mansurah Dakahlia Governorate
Summary
To assess the effect of Febuxostat on clinical outcomes and biomarkers of oxidative stress and inflammation in patients with conservatively managed intracranial hemorrhage.
Eligibility Criteria
Inclusion Criteria:
* • Age ≥ 18 years old.
* Diagnosed with intracranial hemorrhage confirmed by CT scan.
* Managed conservatively regarding clinical guidelines.
* Able to provide informed consent or have a legal representative provide consent.
Exclusion Criteria:
* • Patients with a history of previous brain surgery or significant neurological disorders.
* Severe comorbidities (e.g., uncontrolled diabetes, severe cardiac disease).
* Allergy or contraindication to febuxostat.
* Pregnant or breastfeeding women.
* Patients requiring surgical intervention for hematoma evacuation.
* Renal impairment with SCr \> 4
* Liver impairment with INR \> 5
* Significant deterioration ( GCS \< 8 )
Source: ClinicalTrials.gov (NCT07701512). StuddyBuddy aggregates publicly available trial information.
